Appendix

SSE

by appendixhealth

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GitHub Website SSE

About

Appendix turns any AI health conversation into a board-certified physician's opinion — with a real prescription when clinically appropriate. Search medical literature and submit a clinical encounter for review, all from your agent.

Details

Transport: SSE

Explore

- Searches peer-reviewed medical literature and treatment guidelines.
- Drafts and submits structured clinical letters for physician review.
- Provides board-certified physician opinions with prescriptions when appropriate.
- Knowledge Base access is free; clinical services require a paid subscription.
- No signup required to start using the API.
- Lists available conditions and medications via list_conditions.

Setting up with Highlight

This MCP is not yet compatible with Highlight’s one-click setup. However, you can still use it with Highlight by following these steps:

Download and install Highlight from highlightai.com/download
Navigate to the plugins tab and select "Add Custom Plugin"
Configure the plugin with the settings below

Plugin Name Appendix

Command (node, npx, python, etc.)

Please refer to the README for specific instructions on how to obtain API keys or other required environment variables.
Enable "Start Automatically" if you want the plugin to start when Highlight launches

Setting up with Cursor

Open Cursor's settings
Navigate to the MCP section
Click "Add new Global MCP server"
Copy and paste the configuration below based on your operating system

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

Setting up with Claude Desktop

Open Claude Desktop's settings
Go to the Integrations tab
Click "Add MCP Server"
Use the configuration below based on your operating system

Note: Make sure Claude Desktop is running before attempting to connect.

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

Setting up with Windsurf

Open Windsurf's preferences
Go to the Integrations section
Click "Add MCP Integration"
Use the configuration below based on your operating system

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

Setting up with Cline

Open Cline's settings
Navigate to the Integrations section
Click "Add MCP Server"
Copy and paste the configuration below based on your operating system

Note: Make sure to restart Cline after adding the configuration.

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

Setting up with Goose

Open Goose's preferences
Go to the Integrations tab
Select "MCP Servers"
Click "Add New Server"
Use the configuration below based on your operating system

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

JSON

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

From the repository

Claude Code
``bash claude mcp add --transport http appendix https://mcp.appendix.com/mcp`Claude Desktop / Claude.ai connectors`json { "mcpServers": { "appendix": { "url": "https://mcp.appendix.com/mcp" } } }``

`search_knowledge_base`

Search Appendix's medical knowledge base for clinical literature, treatment guidelines, and reference material to help the user describe their medical issue

`submit_encounter`

Submit a clinical encounter letter to the Appendix physician team for review. The letter should be in Markdown format following the Appendix letter structure. Returns feedback on completeness or a checkout URL when ready. One of our board-certified physicians will personally review the submission and provide clinical guidance and a prescription if appropriate.

`list_conditions`

List all conditions and medications available through Appendix

| Tool | Description |
|------|-------------|
| search_knowledge_base | Search medical literature and treatment guidelines |
| submit_encounter | Submit a clinical letter for board-certified physician review |
| list_conditions | List available conditions and medications |

Learn more at appendix.com.

Claude Desktop / Cursor

Paste into your MCP client config file to install this server.

{
    "mcpServers": {
        "appendix": {
            "appendix": {
                "url": "https://mcp.appendix.com/mcp"
            }
        }
    }
}

McpServers

{
    "appendix": {
        "url": "https://mcp.appendix.com/mcp"
    }
}

Appendix turns any AI health conversation into a board-certified physician's opinion — with a real prescription when clinically appropriate. Your agent searches peer-reviewed medical literature, helps you write a structured clinical letter, and submits it through the Appendix API. A licensed physician personally reviews it and issues a prescription when appropriate, sent to the pharmacy of your choice. The Knowledge Base is free and open to everyone. Clinical services (physician review + prescriptions) are a paid subscription available in supported US states — and you can start using the API with no signup required. ### Install Claude Code ``

bash
  claude mcp add --transport http appendix https://mcp.appendix.com/mcp



  Claude Desktop / Claude.ai connectors

json
  { "mcpServers": { "appendix": { "url": "https://mcp.appendix.com/mcp" } } }



  ### Tools

  | Tool | Description |
  |------|-------------|
  |

search_knowledge_base

 | Search medical literature and treatment guidelines |
  |

submit_encounter

 | Submit a clinical letter for board-certified physician review |
  |

list_conditions` | List available conditions and medications | Learn more at appendix.com.

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About

Details

Explore

Setting up with Highlight

From the repository

search_knowledge_base

submit_encounter

list_conditions

Claude Desktop / Cursor

McpServers

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`search_knowledge_base`

`submit_encounter`

`list_conditions`